Flonase Allergy Relief nasal spray gives you more complete allergy relief than most over-the-counter allergy pills and tablets.** Flonase helps block six key allergic substances. Most allergy pills only block histamines*. Full-prescription strength Flonase provides 24-hour relief from nasal congestion, runny nose, sneezing, itchy nose and itchy, watery eyes all allergy season long. Plus, when used once daily, it outperforms the number 1 non-drowsy allergy pill!† It’s no wonder why Flonase Allergy Relief is the number 1 doctor-recommended allergy brand.†† Flonase nasal spray acts on multiple key inflammatory substances (histamine, prostaglandins, cytokines, tryptases, chemokines and leukotrienes).*Mechanism versus most over the counter allergy pills.